Dose-Response Curve of Chromosome Aberrations in Human Lymphocytes Induced by Gamma-Rays
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چکیده
منابع مشابه
Dose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50MeV proton beams
Background: The purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. Materials and Methods: Human peripheral blood lymphocytes were irradiated using proton beams (LET: 34.6 keV μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (CB) micronucleus (MN) assay. To determine th...
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Background: Radioprotective capability of histamine H2 receptor antagonists have been shown in several in vivo studies mainly using animal models. However, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. In the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...
متن کاملdose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50mev proton beams
background: the purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. materials and methods: human peripheral blood lymphocytes were irradiated using proton beams (let: 34.6 kev μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (cb) micronucleus (mn) assay. to determine the efficie...
متن کاملin vitro radioprotective effects of histamine h2 receptor antagonist against gamma-rays induced chromosomal aberrations in human lymphocytes.
background: radioprotective capability of histamine h2 receptor antagonists have been shown in several in vivo studies mainly using animal models. however, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. in the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...
متن کاملConstruction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
Premature Chromosome Condensation (PCC) appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to 60Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Anal...
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ژورنال
عنوان ژورنال: Atom Indonesia
سال: 2014
ISSN: 2356-5322,0126-1568
DOI: 10.17146/aij.2013.254